Irena Pastar Selected Research

mevastatin (CS 500)

1/2018	Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5.
1/2010	Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor.

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Irena Pastar Research Topics

Disease

31	Wounds and Injuries (Trauma) 01/2022 - 01/2007
11	Ulcer 11/2022 - 12/2008
11	Diabetic Foot 11/2022 - 04/2012
7	Infections 10/2021 - 12/2013
5	Wound Infection (Wound Infections) 01/2021 - 01/2013
4	Inflammation (Inflammations) 01/2021 - 03/2010
4	Varicose Ulcer (Ulcer, Venous) 11/2019 - 01/2007
3	Neoplasms (Cancer) 11/2022 - 01/2007
3	Fibrosis (Cirrhosis) 01/2020 - 01/2007
3	Leg Ulcer 01/2020 - 06/2012
2	Skin Diseases (Skin Disease) 01/2020 - 02/2007
1	Lung Injury 01/2022
1	Sepsis (Septicemia) 10/2021
1	Gangrene 10/2021
1	Opioid-Related Disorders (Opiate Addiction) 10/2021
1	Pressure Ulcer (Bedsore) 11/2019
1	Porokeratosis (Palmoplantar Porokeratosis) 05/2018
1	Diabetes Mellitus 01/2018
1	Burns 09/2015
1	Staphylococcal Scalded Skin Syndrome (Ritter's Disease) 12/2013
1	Polycythemia Vera 06/2012
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2012
1	Cicatrix (Scar) 02/2007

Drug/Important Bio-Agent (IBA)

4	CateninsIBA 11/2022 - 03/2014
4	MicroRNAs (MicroRNA)IBA 01/2021 - 12/2011
3	Pharmaceutical PreparationsIBA 10/2021 - 04/2014
3	Caveolin 1IBA 01/2021 - 01/2018
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 12/2008
2	LipopeptidesIBA 01/2021 - 04/2014
2	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2021 - 03/2011
2	GlucocorticoidsIBA 01/2021 - 02/2007
2	P-2 (P 2)IBA 01/2020 - 01/2019
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2019 - 01/2018
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 09/2016
2	LigandsIBA 01/2018 - 05/2012
2	mevastatin (CS 500)IBA 01/2018 - 01/2010
2	Anti-Bacterial Agents (Antibiotics)IBA 11/2017 - 04/2014
2	Messenger RNA (mRNA)IBA 11/2016 - 12/2008
2	Virulence Factors (Pathogenicity Factors)IBA 12/2013 - 01/2013
2	Keratins (Keratin)IBA 03/2012 - 12/2008
2	Biological ProductsIBA 01/2008 - 01/2007
1	Estrogen ReceptorsIBA 01/2022
1	CatalaseIBA 01/2022
1	angiogeninIBA 01/2022
1	Fentanyl (Sublimaze)FDA LinkGeneric 10/2021
1	Cocaine (Cocaine HCl)IBA 10/2021
1	Peptides (Polypeptides)IBA 01/2021
1	MetallothioneinIBA 01/2020
1	PerforinIBA 01/2020
1	ZincIBA 01/2020
1	SolutionsIBA 11/2019
1	Benzethonium (Magic, Formula)IBA 01/2019
1	Polyurethanes (Polyurethane)IBA 01/2019
1	Edetic Acid (EDTA)FDA Link 01/2019
1	SilverIBA 01/2019
1	mevalonate kinaseIBA 05/2018
1	Long Noncoding RNAIBA 01/2018
1	I-kappa B KinaseIBA 01/2018
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2018
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	Protein Kinase CIBA 01/2017
1	calphostin CIBA 01/2017
1	Phospholipases (Phospholipase)IBA 01/2017
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2017
1	farnesyl pyrophosphate (farnesyl diphosphate)IBA 11/2016
1	Caffeine (No Doz)FDA LinkGeneric 10/2016
1	ProcalcitoninIBA 09/2016
1	InterleukinsIBA 09/2016
1	Biocompatible Materials (Biomaterials)IBA 09/2016
1	Matrix Metalloproteinases (MMPs)IBA 09/2016
1	Small Interfering RNA (siRNA)IBA 09/2015
1	EnzymesIBA 09/2015
1	CytokinesIBA 12/2013
1	leukotoxinIBA 12/2013
1	Panton-Valentine leukocidinIBA 12/2013
1	ExfoliatinsIBA 12/2013
1	Anti-Infective Agents (Microbicides)IBA 01/2013
1	Fibroblast Growth Factor 7 FDA Link 01/2013
1	Hydroxyurea (Hydrea)FDA LinkGeneric 06/2012
1	Therapeutic UsesIBA 05/2012
1	Rosiglitazone (Avandia)FDA Link 05/2012
1	CollagenIBA 05/2012
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2012
1	Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA 03/2011
1	Transforming Growth Factor beta (TGF-beta)IBA 03/2010
1	Filaggrin ProteinsIBA 12/2008
1	involucrinIBA 12/2008
1	Differentiation AntigensIBA 12/2008
1	Proline (L-Proline)FDA Link 12/2008
1	Tissue Inhibitor of Metalloproteinase-2IBA 02/2007
1	ProcollagenIBA 01/2007

Therapy/Procedure

14	Therapeutics 11/2022 - 01/2008
5	Surgical Amputation (Amputations) 10/2021 - 01/2015
4	Debridement 06/2012 - 01/2007
1	Injections 10/2021
1	Aftercare (After-Treatment) 01/2020
1	Transplantation 01/2019
1	Mohs Surgery (Mohs' Micrographic Surgery) 06/2012
1	Cell- and Tissue-Based Therapy (Cell Therapy) 11/2011